I haven't been using Manga Studio 3 EX for a while. The last time I used it was way before I got the ATI HD 4850 graphic card and the DELL 24 inch UltraShape display as my second displace. So when I found out that Manga Studio went nuts when I tried to use my Wacom Graphite 4 8" x 6" tablet with it. I wan't too surprise. What surprised me was the solution.
The moment I encountered the problem, I went ahead and downloaded the driver to update the Wacom driver to 22.214.171.124. Well, does NOT solve the problem.
Then I went to Smith Mirco's site and found that there's NO UPDATE on Manga Studio 3 EX... great.
Finally I found my rescure in CP Forums. Someone found out that by removing Wacom Tablet Perference, reboot, and set the preference again, it will resolve the problem. But how do I remove the preference?
Well, Wacom provided instruction to remove the Wacom tablet perference. I basically followed it, but went 1 step future by removing both Tablet.dat and Pen_Tablet.dat. After removing all these perference files, reboot, and then set the Tablet setting, Manga Studio works again. In fact, I am continue using my dual screen setting with no problem.